New Mexico Supercomputing Challenge

KABOOM! Computerized Simulator for Nano-Delivery for Pancreatic Cancer

Team: 12

School: Capital High

Area of Science: Nanotechnology

Problem Definition:

Chemotherapy is an aggressive therapy that destroys cells within the body. Chemotherapy is mainly used to treat cancer by stopping and slowing down the replication of the cancerous cells that are found in the body. Unfortunately, this treatment also interferes with healthy cells in the organism. Over the past four years, scientists have been testing new and revolutionary treatments to control cancer proliferation throughout target therapy.

In order to target and eliminate the cancer cells, a vector virus is been used as the chemotherapy carrier to destroy the formation of cancer cells. Studies(1)(2) have been done using vector viruses to eliminate cancer cells, but none of them have been proven successful so far. For instance, US National Library of Medicine published new research trials such as “Bugs and Drugs: Oncolytic Virotherapy in combination with chemotherapy” but in order to "maximize the therapeutic efficacy of OV-drug combination therapies, further investigations will be necessary.

The objective of the “KABOOM!! Computerized simulator for Nano-Chemotherapy” (K+CSN-CH) project is to design a computer program that will simulate the whole picture of the reaction of the Nano-chemotherapy inside the body. This programming project will help new medical trials to maximize scientific research to ensure new strategies to cure cancer.

Progress to Date:

A programming simulator will be constructed to amplify a computerized image that will show how the vector virus will be targeting cancer cells. This program also will help the scientist to analyze more closely the reaction of the cancerous cells when the vector virus will deliver the Nano-chemotherapy. The cancer that will be analyzed throughout this program will be related to pancreatic cancer. Pancreatic cancer is categorized as one of the cancers that proliferate quickly. Although it can be treated early, the prognosis to control the pancreatic cancer expansion is very low. “K+CSN-CH” will be the technology needed to implement a new idea to help and find other ways to create a treatment for Pancreatic cancer.

Expected Results:

Once the program is designed, created and tested, it will proved that simulation will be the best way to make medical experiments using a computer programming without affecting the human living organism for experimentation. K+CSN-CH will embrace the future of scientific research to make experiments quick and efficient that can help them obtain accurate results to improve a terminal human condition such as cancer.

1. National Center for Biotechnological Information (2010) “Oncolytic herpes simplex virus vectors and chemotherapy: are combinatorial strategies more effective than cancer?” (Kanai R., Wakimoto H., Cheema T., Rabkin SD.)

2. US National Library of Medicine (2012) "Bugs and Drugs:Oncolytic Virotherapy in combination with Chemotherapy" ( Wennier ST.,Liu J., McFadden G.)

Team Members: Liliana Reza, Yesenia Diaz, Brenda Zamarron, Cristina Medina, Angelica Chacon

Team Sponsor: Irina Cislaru

Team Members:

  Angelica Chacon
  Liliana Reza
  Cristina Medina
  brenda zamarron
  Yesenia Diaz

Sponsoring Teacher: Irina Cislaru

Mail the entire Team

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